Laboratories

Cellular Biology and Parasitology

  • The laboratory has as its main area of interest, the morphological and ultrastructural study of nematodes and trematodes, parasitic human and wild and domestic animals. These studies are taxonomic clarification of positions in order to increase knowledge of biodiversity and eco-epidemiology of helminth parasites Brazilian and add information on the ultrastructure of these helminths.

    Head of laboratory - Wanderley de Souza - Lattes

  • These research lines focus the study of fungal cell biology, molecules involved in the cell interaction process and more recently, the study of new antifungal targets. With this goal we have tried to integrate the study of cell structures, isolation and biochemical characterization of cell surface structures and the role of these structures on fungal virulence and cell interaction process. 

    Head of laboratory - Sonia Rozental - Lattes

  • The research areas of the laboratory are:Mechanisms involved in mediating host insect parasite; Regulation of endocytic process by local mediators in insects and Characterization of enzymes during embryogenesis of insects.

    Head of laboratory - Ednildo de Alcantara Machado - Lattes

  • We are interested in understanding how changes in metabolism and biosynthesis of glycoconjugates result in oncogenic transformation and induction of invasion and metastasis. The epithelial mesenchymal transition (EMT), related to the loss of polarity and increased cell motility, has helped to clarify these mechanisms. We seek to study changes in glucose influx of the HBP and its metabolites modulating the intracellular (O-GlcNAc) and extracellular glycosylation during TEM.

    Head of laboratory - Adriane Regina Todeschini - Lattes

  • Different lines of research have been developed grouped into three main projects: the study of the structural organization of parasites, their interaction with host cells and the development of new drugs that could be used in chemotherapy.

    Head of laboratory - Wanderley de Souza - Lattes

Structural and Molecular Biology

  • The  Laboratory of Biologic Physics is focused on the development of new tools, comprising computational and experimental advanced methods, aiming to improve the understanding of biological processes at molecular level.

    Head of laboratory - Paulo Mascarello Bisch - Lattes

  • The main objectives are: Molecular pathology of cancer; Relationship between smoking and gene silencing in the development of lung cancer; Proteomic profile of lung cancer related to smoking or not; Study identifying potential chemotherapeutics; Virology and cancer; Human cancers associated with viral infection.

    Head of laboratory - Maria da Glória da Costa Carvalho - Lattes

  • The laboratory is dedicated to the study of the control of gene expression in eukaryotes, using as model the parasite Trypanosoma cruzi, the causative agent of Chagas disease. Another aspect of the lab is to develop projects in close collaboration with the medical clinic in the areas of Cardiology and Molecular Hepatology.

    Head of laboratory - Rosane Silva - Lattes

  • Head of laboratory - Eleonora Kurtenbach - Lattes

  • Research into developing processes for the synthesis of RNA and proteins that regulate replication cycle and formation of new particles (morphogenesis); assessment of viral transcription in vitro systems and in vivo; comparative analysis of some virulence factors in CTGV and 10C viruses; comparative evaluation of the response of Cantagalo viruses to antiviral drugs and 10C; understanding the role that CypA and other CYPs as CYPB and Cyp40, play in the viral replicative cycle. Furthermore, we analyzed the antiviral potential of other drugs like Brequinar, Cidofovir and piperine.

    Head of laboratory - Clarissa Damaso - Lattes

  • The main objectives are: Simulation in research of molecular structures; simulation of biological membranes and proteins and peptides; to implement studies of protein folding.

    Head of laboratory - Pedro Geraldo Pascutti - Lattes

  • The laboratory has investigated the role of NF-kB in the model of DNA damage generated by topoisomerase 11 inhibitor, etoposide, and in response to the infection of human cells with human pathogens such as Mycobacterium leprae and Leishmania. Interests us investigate the regulatory pathways that lead to activation of this factor, as well as the characterization of the dimers of NF-kB in these functional stimuli and particularly the identification of genes regulated by these functional dimers.

    Head of laboratory - Ulisses Gazos Lopes - Lattes

  • The laboratory conducts research on : Lethal and mutagenic effects of reactive oxygen species; DNA repair systems in bacteria and yeast; Repair of damage caused by chemotherapy in bacterial DNA; Effects of UVB radiation in bacteria.

    Head of laboratory - Alvaro Augusto da Costa Leitão - Lattes

  •   The main fields of research are: Biophysics, Molecular and Cellular Biology, Biochemistry, and Structural Biology, focusing on the studies of protein folding, interactome, virus-cell interaction, protein-protein and protein-DNA interactions, discovery of antiviral inhibitors.

    Head of laboratory - Ronaldo da Silva Mohana Borges - Lattes

Environmental Biophysics

  •     The research activities in developing LETC are: studies on the occurrence of toxic cyanobacteria in aquatic ecosystems Brazilian influence of environmental factors on growth and toxin production by cyanobacteria, isolation of toxigenic strains, extraction, purification and quantification of toxins produced, processes bioaccumulation of these toxins by aquatic biota and consequences for public health.

    Head of laboratory - Sandra Maria Feliciano de Oliveira e Azevedo - Lattes

  • Our laboratory uses molecular approaches to study the relationship between genes and environment in non-traditional models of research, through the effect of pollutants on aquatic organisms, aiming at the formation of an expert group on an ecosystem approach to health problems.

    Head of laboratory - Mauro de Freitas Rebelo - Lattes

  • Our laboratory aims to assess the human and environmental contamination by heavy metals and organic micropollutants. Among the metals studied, highlight: Cd, Cu, Cr, Pb, Fe, Mn, Ni, Zn, Se, Hg and among the organic micropollutants can cite organochlorine pesticides (DDT's, DRIN's, Lindane, Endosulfan, HCB, etc. .) or industrial origin as policlorobifenilas (PCBs) and polycyclic aromatic hydrocarbons (PAH's).

    Head of laboratory - Olaf Malm - Lattes

  • The laboratory is dedicated to the application of radioactive isotopes - stable and more recently also in environmental sciences, in particular in the study of the cycle and the chemical speciation of metallic pollutants in aquatic environments, being a pioneer in studies of microbial methylation of Hg.

    Head of laboratory - Jean Remy Davée Guimarães - Lattes

Physiology and Cellular Biophysics

  • The main objective of the laboratory is to elucidate the mechanisms involved in cell signaling modulation of the transport of sodium and albumin by angiotensins, autacoids and natriuretic factors.

    Head of laboratory - Celso Caruso Neves - Lattes

  • The Laboratory of Biomembranes (LaBiom) has as main topic the cellular signaling and the elements that comprise different cell signaling pathways based on the Plasma Membrane, with emphasis on the study of receptors, lipids, microdomains (rafts and caveolae), protein kinases, lipid kinases and intracellular targets in the different biological models used.

    Head of laboratory - Marcelo Einicker Lamas - Lattes

  • The Laboratory conducts research on : Thyroid carcinogenesis: molecular markers and new therapeutic perspectives; Ageing and thyroid function; Involvement via Ras-pERK in thyrocytes proliferation and differentiation; Generation of hydrogen peroxide and thyroid hormone biosynthesis; Modulators of  thyroid function; Overweight: hormonal regulation of energy expenditure.

    Head of laboratory - Denise Pires de Carvalho - Lattes

  • Our studies seek to understand the operation in physiological and pathophysiological situations, the hypothalamic-pituitary-thyroid hormone action and thyroid.

    Head of laboratory - Carmen Cabanelas Pazos de Moura - Lattes

  • The central area of interest of the Laboratory is the study of the function and modulation of the enzymatic activity of numerous ion transporters ATPases in physiological and pathological processes in different biological models

    Head of laboratory - Adalberto Ramon Vieyra - Lattes

  • The Laboratory of Respiratory Physiology, via a multi-and interdisciplinary approach, aims the understanding of respiratory consequences of disease, and hence the application of such knowledge to human beings.

    Head of laboratory - Walter Araujo Zin - Lattes

Imunobiology

  • The Laboratory of  Biology of the Immune System has as areas of research; Immunology, Microbiology and Experimental Medicine. The research focus on programmed cell death (apoptosis) in the immune system, cell biology processing of dead cells, and its importance in mechanisms of human infectious and inflammatory diseases.

    Head of laboratory - George Alexandre dos Reis - Lattes

  • Conducts research for : Development of genetic vaccines and nanopartlculadas use noninvasive against leishmaniasis; Development of new drugs for leishmaniasis and application of nanotechnology for its improvement; Mechanism antianafilático plant Kalanchoe pinnata and the role of purinergic receptors in leishmaniasis:

    Head of laboratory - Bartira Rossi Bergmann - Lattes

  • The research areas of the Laboratory are focused on the study of the regulation of the production and the role of lipid mediators in innate immunity cells in inflammatory, allergic and infectious, and tumor development.

    Head of laboratory - Bruno Lourenço Diaz - Lattes

  • The Laboratory of Immunobiology is currently studying how inhibition of apoptosis induced by Fas Ligand/Fas (receptor)/caspase-8 affects cytokine responses mediated by CD4 and CD8 T cells, as well as monocytes and macrophages in experimental infections by Trypanosoma cruzi and Leishmania major.

    Head of laboratory - Marcela de Freitas Lopes - Lattes

  •   Our current research lines are grouped in two main axes: a more basic line, involving the molecular and biophysical characterization of these receptors, and a more functional line, in which we apply our basic knowledge in different situations of immuno-pathological interest such as antigen presentation, vaccination, and the infection with intracellular pathogens such a as the human immunodeficiency virus (HIV) and the protozoan that causes malaria (Plasmodium).

    Head of laboratory - Pedro Muanis Persechini - Lattes

  • Head of laboratory - Célio Geraldo Freire de Lima - Lattes

  • The aim is to study the immune system and its interactions with others systems.  In particular, using a multidisciplinary approach, the extracellular nucleotides’ functions are investigated (common mediators of the immune, nerve and endocrine system) in physiological context and in pathological conditions. 

    Head of laboratory - Robson Coutinho Silva - Lattes

  • Centered in the investigation of the mechanisms of immunopathogenesis in Chagas Disease, surveys conducted by the team aim to clarify the contribution of Kinin System (KS) in the delicate balance of the host-parasite relationship.

    Head of laboratory - Julio Scharfstein - Lattes

  • The research areas of the Laboratory are: Identification and characterization of new chemotherapeutic its signaling pathway; Identification and characterization of the mechanism of action of compounds with anti-MDR activity.

    Head of laboratory - Cerli Rocha Gattass - Lattes

  • Conducts studies using multi-disciplinary approaches that include genetic manipulation of parasites, molecular biology, protein biochemistry, enzymology and cell biology in order to investigate the biological role of CPs and their endogenous inhibitors in parasitic protozoa.

    Head of laboratory - Ana Paula Cabral de Araujo Lima - Lattes

Neurobiology

  • Main interest: Interaction of Emotion Brain, Vision and attention; Cognitive aspects in the control of posture and voluntary movements.

    Head of laboratory - Eliane Volchan - Lattes

  • The Laboratory of Neurobiology Retinal studies the development, plasticity and morpho-functional organization of the retina of different species. The main aspects are analyzed the distribution of neurotransmitters and receptors in retinal structure, the connections between cell types recognized by their neurotransmitters, the ontogeny of cells expressing certain neurotransmitters. Furthermore, studies the effect caused by the application of hormones, drugs of abuse, environmental pollutants, and agonists and antagonists of neurotransmitters on the genesis and differentiation of retinal tissue during embryonic development

    Head of laboratory - Patricia Franca Gardino - Lattes

  • Research areas : Differentiation of Peripheral and Central Nervous Systems; Neuro-glial interactions; Neurotransmitters and trophic factors

    Head of laboratory - Fernando Garcia de Mello - Lattes

  • The Laboratory of Neurogenesis has over 20 years of tradition in experimental studies on neurodegeneration and neuroprotection. The work is aimed at understanding the mechanisms of neurodegeneration and its modulation by intrinsic and exogenous factors and the main experimental model has been the vertebrate retina, a model of nervous tissue representative of the entire CNS. The results are contributing much to elucidate aspects of the biology of programmed cell death Tissue-specific retina, the broader aspects of neurodegeneration and neuroprotection generally applicable to the CNS.

    Head of laboratory - Rafael Linden - Lattes

  • The objective of the Physiology Laboratory of Cognition is the study of dead-functional organization of the cortex and subcortical structures of primates and their cognitive aspects.

    Head of laboratory - Ricardo Gattass - Lattes

Cellular Therapy and Bioengineering

  • Research lines: Cellular mechanisms for cardiac arrythmias; Ischemia and Reperfusion of myocardium: endogenous and exogenous factors for cardio protection; Cell signaling involving ion channels and receptors; Cardiovascular conditioning by exercise: effects of anabolic steroids in hypertrophy and ionic  remodeling; Experimental pulmonary arterial hypertension: Physiopathological mechanisms and therapeutic strategies; Autoimmunity in Chagas disease; Isolation and electrophysiological characterization of cardiac stem cells from human and mice; Functional effects ofauto-antibodies from patients with Idiopathic Dilated Cardiomyopathy in rabbit cardiomyocytes.

    Head of laboratory - Jose Hamilton Matheus Nascimento - Lattes

  •    There are three lines of research in our laboratory to study cellular and molecular approaches: Role of gangliosides in the development and regeneration of the nervous system; Role of nitric oxide during development of the nervous system and Cell therapies in chronic degenerative diseases and traumatic injuries of the nervous system:

    Head of Laboratory: Rosália Mendez Otero - Lattes

  •   The studies performed in our laboratory are orientated to establish the molecular bases of ion transport mechanism involved in different physiological processes. In this context in our group we study the gene expression modulation of chloride transporters in the kidney by hormones involved in extracellular volume regulation (aldosterone, vasopressin, thyroid hormone, and estrogen) and also in animals (rat) subjected to acidosis and alkalosis.

    Head of laboratory - Marcelo Marcos Morales - Lattes

  • The laboratory has studied the toxic effects and mechanisms of action of compounds that interfere with the biosynthesis / expression ghcoconjugados T. cruzi and Leishmania spp. with chemotherapeutic potential, such as analogs éterlipídeos (1-0 - hexadecylphosphocholine or miltefosine); natural and synthetic alkaloids, and fungicidal compounds which inhibit the biosynthesis of sphingolipids.

    Head of laboratory - Lucia Mendonça Previato - Lattes

  • Currently, the research lines developed in the laboratory are focused in four main areas: Autoimmune diseases that affect the heart; Cell therapies for heart disease; Cellular therapies for liver diseases; Cell Therapy for severe muscle injuries.

    Head of laboratory - Regina Coeli dos Santos Goldenberg - Lattes

  •      In Pulmonary Research Laboratory has been studying the respiratory system under normal and pathological point of view: functional, histological, biochemical and molecular. Usually we create animal models of diseases found all in clinical or surgical tested and the results of the use of drugs, anesthetic agents and pharmacologic therapies in general and ventilation.

    Head of laboratory - Patricia Rieken Macedo Rocco - Lattes

Multiuser units

  • The main objective is to offer an instrumental infrastructure of last generation to mass spectrometry techniques for the training of highly qualified personnel with solid academic foundation and technical-scientific, able to meet the needs of a country like Brazil.

  • The lines of research undertaken by the permanent staff of the unit concentrated on the study of gene regulation and expression of bacteria, continuing the previous projects. It covers the following topics: the study of genomes and proteomes of bacteria, particularly pathogenic by molecular biology techniques and bioinformatics studies of the interaction ONA-protein in the context of gene regulation and bacterial analysis extragênicas regions of bacteria and their function in regulation.

    Chefe de Laboratório - Paulo Mascarello Bisch - Lattes

  • The Immuno-Analysis Platform (IAP) is a multi-user unit that gathers and supports the use of equipment and techniques using immunological reagents. Currently, PIA has two flow cytometers capable of analyzing 4:06 colors simultaneously, and a system of digital image acquisition for chemiluminescence immunodetection of proteins ("Western blotting").

  •   This is a multiuser space that aims to support projects and research areas that require equipment and / or infrastructure for expression, purification and analysis of macromolecules. The regiment Platform is being drafted and more information will be available soon.

Center for Animal Experimentation

  • It aims to provide primary technical support for mating, euthanasia, weaning, cutting tails, etc. of genetically modified (AnGM) to establish colonies of them. This laboratory meets regulatory instructions of Law 8974/95 which deals with standards for work and containment AnGM animals and today hosts researchers from different departments and institutes that make up the Center of Health Sciences (CCS). Furthermore, the LAT is intended for maintenance and supply of inbred mice of different strains to the entire scientific community.